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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HIF1A
All Species:
19.39
Human Site:
S438
Identified Species:
42.67
UniProt:
Q16665
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16665
NP_001521.1
826
92670
S438
Y
N
D
V
M
L
P
S
P
N
E
K
L
Q
N
Chimpanzee
Pan troglodytes
A2T6X9
766
85495
G408
D
H
D
S
Q
W
G
G
S
P
L
T
D
T
A
Rhesus Macaque
Macaca mulatta
XP_001099149
826
92672
S438
Y
N
D
V
M
L
P
S
S
N
E
K
L
Q
N
Dog
Lupus familis
XP_852278
823
92040
S438
Y
N
D
V
M
L
P
S
S
N
E
K
L
Q
N
Cat
Felis silvestris
Mouse
Mus musculus
Q61221
836
93498
S438
Y
N
D
V
M
F
P
S
S
N
E
K
L
N
I
Rat
Rattus norvegicus
O35800
825
92301
S438
Y
N
D
V
M
F
P
S
S
N
E
K
L
N
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510942
994
109832
S624
N
D
V
M
L
P
S
S
S
E
K
L
Q
N
L
Chicken
Gallus gallus
Q9YIB9
811
90524
S438
D
V
M
L
P
S
S
S
E
K
L
Q
N
I
N
Frog
Xenopus laevis
Q9I8A9
805
90946
S439
D
V
M
L
H
S
T
S
N
K
L
E
S
T
P
Zebra Danio
Brachydanio rerio
Q98SJ5
745
82716
S387
K
T
R
L
S
P
Y
S
Q
Y
P
G
F
P
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24167
1507
165805
I517
A
T
S
T
A
D
Q
I
K
Q
L
P
E
S
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
25.7
99.1
95.5
N.A.
89.5
90.3
N.A.
67.4
78.3
61.7
26.8
N.A.
24.1
N.A.
N.A.
N.A.
Protein Similarity:
100
42.6
99.3
97
N.A.
92.4
93.5
N.A.
73.9
89.3
74.9
44.1
N.A.
36.7
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
93.3
93.3
N.A.
73.3
73.3
N.A.
6.6
13.3
6.6
6.6
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
13.3
93.3
93.3
N.A.
73.3
73.3
N.A.
33.3
26.6
20
13.3
N.A.
6.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
10
0
0
0
0
0
0
0
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
28
10
55
0
0
10
0
0
0
0
0
0
10
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
10
10
46
10
10
0
0
% E
% Phe:
0
0
0
0
0
19
0
0
0
0
0
0
10
0
0
% F
% Gly:
0
0
0
0
0
0
10
10
0
0
0
10
0
0
0
% G
% His:
0
10
0
0
10
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
10
0
0
0
0
0
10
19
% I
% Lys:
10
0
0
0
0
0
0
0
10
19
10
46
0
0
0
% K
% Leu:
0
0
0
28
10
28
0
0
0
0
37
10
46
0
10
% L
% Met:
0
0
19
10
46
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
46
0
0
0
0
0
0
10
46
0
0
10
28
46
% N
% Pro:
0
0
0
0
10
19
46
0
10
10
10
10
0
10
10
% P
% Gln:
0
0
0
0
10
0
10
0
10
10
0
10
10
28
0
% Q
% Arg:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
10
10
10
19
19
82
55
0
0
0
10
10
0
% S
% Thr:
0
19
0
10
0
0
10
0
0
0
0
10
0
19
10
% T
% Val:
0
19
10
46
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% W
% Tyr:
46
0
0
0
0
0
10
0
0
10
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _